The CRUK Cambridge Institute (CI), a department of the University of Cambridge, is one of Europe's top cancer research institutes. We are situated on the Addenbrooke's Biomedical Campus and are part of both the University of Cambridge School of Clinical Medicine, and the CRUK Cambridge Centre. The Institute is home to 18 research groups which cover a spectrum of research from basic experimental and computational cancer biology through translational cancer research to clinical application. The Institute's scientific Core Facilities work in partnership with the Institute's Research Groups and are a repository for deep technological expertise and knowledge, playing a fundamental role at the heart of the Institute's research community.
The CI Genomics Core (CIGC) provides Next-Generation Sequencing (NGS) services for CRUK CI as well as the wider University and collaborative laboratories across The Cambridge Biomedical Campus. The CIGC supports translational research by providing a variety of single cell library prep services using but not limited to 10X Genomics workflows, bulk DNA/RNA library preps (from multiple suppliers) and sequencing service (MiSeq, MiSeq i100, NextSeq2000, NovaSeqX Plus and ONT PromethION24). We support cell isolation using CellenOne for downstream single cell applications and currently expanding the portfolio of spatial single cell platforms offering 10X Visium SD, 10X Visium HD and 10X Xenium etc.).
You'll be joining us at an exciting time as we continue to expand our genomics service encompassing ever larger scale genomics projects, and continue to develop our utilisation and innovation of sequencing technologies, library preparation methods, single cell and spatial techniques; providing genomic data for CRUK CI and the University of Cambridge. Genomics is our passion and generating exceptionally high-quality data to translate research is our mission. The CIGC has an established promotional pathway leading from the Research Assistant level to a Senior (Single Cell&Spatial or Library prep&Sequencing) Specialist.
The role holder will assist in the provision of these services as well as carrying out research support directly. This will include the introduction of new methods and technologies to enhance the quality of research at the Institute. Daily duties will involve single cell library preparation using standard kits from different suppliers, single-cell sample receipt and processing, RNA / DNA sample quality control, LIMS curation, and sequencing these samples on Illumina and ONT sequencers, data analysis of quality, and interaction with users of the services. The post-holder will be involved in pilot experiments, testing and implementing new technologies including novel library preparation for single cells and spatial single cell platforms. In the first instance the role holder will support single cell and spatial activities.
The ideal applicant will have a degree in biological or biotechnological sciences and be experienced with a diversity of molecular biology techniques including PCR/qPCR, and DNA/RNA library preparation, single cell library preparation, NGS short and/or long read sequencing. They will be an excellent communicator and team player and bring a positive impact to the Core. It would be highly desirable for the post-holder to have practical experience with single cell/DNA/RNA/ (dissociated and spatial) library preparation, Illumina next-generation sequencing systems, ONT long read sequencing, and sample preparation for downstream single cell analysis. They will use their scientific knowledge, expertise and broad practical molecular biology skills to provide a truly excellent genomics service, as well as helping the CIGC to set and maintain an excellent genomics service.
This post may require some out-of-hour working and travel to national seminars/meetings.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Fixed-term: The funds for this post are available for 1 year in the first instance. Upon renewal of current funds and successful evaluation of performance, the position may become longer-term.
Interviews are expected to be held in the first week of July 2025.
If you have any queries regarding the application process or queries relating to this vacancy, please contact: [email protected].
Please quote reference SW46238 on your application and in any correspondence about this vacancy.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
